Acetaminophen vs. NSAIDs (Ibuprofen); Side Effects & Overdose

Use of Acetaminophen

Although NSAIDs, especially Ibuprofen, is the first preference in the treatment of Acetaminophen, it is still the second choice of drug in people who face serious NSAID-related adverse effects.

NSAIDs are notoriously known for their effect on gastric irritation. Their long-term use can cause gastric ulceration by destroying the inner mucosal layer of the GI tract. People who directly need the use of NSAID are then prescribed a Proton Pump Inhibitor like Omeprazole in order to protect the gastrointestinal mucosa. If the use of NSAID is not compulsory,  physicians advise patients to use the safe drug acetaminophen first.

NSAID is an anti-inflammatory drug, so conditions like rheumatoid arthritis are better treated with it. Advil and Motrin (the brand names of Ibuprofen) are usually recommended for pain management to arthritis patients. Unlike Ibuprofen and other NSAIDs, Acetaminophen (a well-known brand name called Tylenol) does not work as well as the NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis. As a result, pains associated with migraines and menstruation are treated better with NSAIDs, but again Acetaminophen remains the safest option of all.

Written by Martin Davis