Different from other types of cancer, leukemia is already in the blood during the first stage of the disease, which is why it is commonly spread to other tissues. When leukemia cells take the bone tissue, patients would likely complain from bone pain, bone mineralization problems, and susceptibility to fractures.
Leukemia patients with or without a spread to the bones will likely have body aches. Cancer cells in the bone marrow, blood flow impairments to the legs, and the side effects of chemotherapy and radiotherapy contribute to body aches. However, in some cases, myeloma (a mass of cancer cells) starts to form in the bone marrow, which aggravates bone pain and complicates the prognosis of the patient.