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Extrahepatic causes

• Cholelithiasis: A blockage of the bile ducts caused by gallbladder stones. The bile is not eliminated and starts leaking into the blood.
• Pancreatitis: The pancreas and the gallbladder have a common passageway. Thus, when the bile ducts are blocked, this may also affect the pancreas and vice versa.
• Pancreatic or biliary malignancies: When a tumor forms in the pancreas or the liver, it pushes the structures away and creates a blockade.
• Portal adenopathy: This is basically a lymph node that grows very large and blocks the typical passage of bile to the intestines.
• Biliary strictures: After surgery, inflammation may cause a stricture in the biliary ducts. When this happens, the normal flow of bile becomes compromised.