Nerve Irritations
Another cause of hiccups happening beyond 48 hours is when there is nerve irritation, particularly affecting the phrenic nerve or the vagus nerves which supply the diaphragm. The following are examples of conditions that can result in nerve irritation:
- Tumors
- Neck masses, such as thyroid
- GERD, gastroesophageal reflux disease
- Laryngitis which means inflammation of the larynx
- Sore throat
- Cystic swelling around the neck.



