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2) Fatigue
This is a sensation of tiredness that does not improve after resting or sleeping at night, even after a good night’s sleep. The main reason these patients develop fatigue is related to the systematic destruction of red blood cells that is mainstream in this infection. As noted above, Plasmodium species use red blood cells to replicate inside. They destroy blood cells and continue moving forward, infecting more of them. This leads to anemia, which can be very severe in some cases.
As a result of anemia, patients have an inadequate oxygen supply to organs that require high consumption, such as the brain and the muscle tissue. This causes the sensation of lightheadedness and muscle weakness that people describe as tiredness.
